Shaky Foundations: Confronting the Replication Failures Threatening the Integrity of US Clinical Research
A growing body of evidence suggests that a substantial proportion of peer-reviewed clinical trial findings cannot be reliably reproduced, exposing systemic vulnerabilities in study design, reporting practices, and institutional incentives. This analysis examines the structural causes of the reproducibility crisis and outlines evidence-based strategies for strengthening the scientific foundation of clinical medicine in the United States.